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KMID : 0364019750080020135
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Korean Journal of Thoracic and Cardiovascular Surgery
1975 Volume.8 No. 2 p.135 ~ p.141
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Experimental Studies on Extracorporeal Circulation by Sarns heart-Lung Machine with Total Prime of Hartman´s Solution
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金近鎬/Kim, Kun Ho
朴永寬/池幸玉/金英泰/李宗培/鄭崙采/Park, Young Kwan/Lee, Heng Ok/Kim, Young Tae/Rhee, Bae Rhee/Chung, You Chae
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Abstract
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Total body perfusion using Sarns Heart-Lung-Machine, five head pump motor system with Travenol disposable bubble oxygenator was attempted in the dogs by the hemodilution method with total prime of buffered Hartman´s solution under moderate hypothermia.
The first of all, the functions of Sarns Heart-Lung-Machine and effects of the hemodilution perfusion by buffered Hartman´s solution was studied. At the same time the changes of pressure of artery and vein, gas contents of the blood, and influence on the blood pictures were observed before, during, and after perfusion in 1-2 days.
Hemodilution rates were the ranges of 85.0m1/kg to 97.3ml/kg and perfusion flow rates were maintained with the average 80.5ml/kg/min (the ranges of 73.3m1/kg/min to 92.8ml/kg/min). Hypothermia was employed between 35℃ and 31℃ of the esophageal temperature. The total body perfusion was continued for 50-60 minutes. In the total cardio-pulmonary bypass, atriotomy, ventriculotomy, and atrioventriculotomy were performed respectively.
Arterial pressure was ranged approximately between 50 mmHg and 140 mmHg, but generally, it was maintained over 75 mmHg. Venous pressure was measured between 3.8 cmH_(2)O and 16.0 cmH_(2)O.
Optimum oxygenation could be achieved when oxygen flow into the oxygenator was maintained, approximately at 5.5L/min. In this way, the pO_(2), pCO_(2), and oxygen saturation were measured before, during, and afterperfusion in 1-2 days.
The pCO_(2) ranged approximately between 26.0 mmHg and 38.5 mmHg, but generally, it was maintained in the average 30.932.5mmHg The pO= was ranged between 73.0mm.Hg and 332.2 mmHg, but it was maintained in the average 103.0-219.0 mmHg. Oxygen saturation was measured over 95.0% during and after extracorporeal circulation respectively.
Erythrocyte count, hemoglobin, hematocrit, and leucocyte count were decreased to 49.2%. 49.0%. 49.4%. and 21.1% of the preoperative value during extracorporeal circulation respectively and these reductions were not recovered until 1-2 days after perfusion These decrease We resulted from relatively high degree of hemodilution rate and operative bleeding during these experimental studies. The platelets count was also decreased about to 71% during perfusion, on the contrary, it was increased progressively after perfusion and in 1~2 days, after perfusion the value was returned to preoperative control level.
Three dogs were all recovered after extracorporeal circulation.
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